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Article

Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells.

PloS one - 1 Jan 2017

Moussette Sanny, Al Tuwaijri Abeer, Kohan-Ghadr Hamid-Reza, Elzein Samar, Farias Raquel, Bérubé Julie, Ho Bianca, Laprise Catherine, Goodyer Cynthia G, Rousseau Simon, Naumova Anna K

Abstract excerpt

Chromosomal region 17q12-q21 is associated with asthma and harbors regulatory polymorphisms that influence expression levels of all five protein-coding genes in the region: IKAROS family zinc finger 3 (Aiolos) (IKZF3), zona pellucida binding protein 2 (ZPBP2), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and gasdermins A and B (GSDMA, GSDMB). Furthermore, DNA methylation in this region has been...

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Source

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Identifiers

PMID: 28241063
DOI: 10.1371/journal.pone.0172707
PMCID: PMC5328393

Genes

ZPBP2
GSDMA
ORMDL3
IKZF3
CTCF
GSDMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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