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Article

17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Feb 2022

Laubhahn Kristina, Böck Andreas, Zeber Kathrin, Unterschemmann Sandra, Kunze Sonja, Schedel Michaela, Schaub Bianca

Abstract excerpt

BACKGROUND: Childhood wheeze represents a first symptom of asthma. Early identification of children at risk for wheeze related to 17q12-21 variants and their underlying immunological mechanisms remain unknown. We aimed to assess the influence of 17q12-21 variants and mRNA expression at birth on the development of wheeze. METHODS: Children were classified as multitrigger/viral/no wheeze until six years of age. The...

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PMID: 34919286
DOI: 10.1111/pai.13721

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