Article
Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2009
Hayashi Yoshitaka, Yamamoto Michiyo, Mizoguchi Hiroyuki, Watanabe Chika, Ito Ryoichi, Yamamoto Shiori, Sun Xiao-yang, Murata Yoshiharu
Abstract excerpt
Multiple bioactive peptides, including glucagon, glucagon-like peptide-1 (GLP-1), and GLP-2, are derived from the glucagon gene (Gcg). In the present study, we disrupted Gcg by introduction of GFP cDNA and established a knock-in mouse line. Gcg(gfp/gfp) mice that lack most, if not all, of Gcg-derived peptides were born in an expected Mendelian ratio without gross abnormalities. Gcg(gfp/gfp) mice showed lower...
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