Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.

Cell metabolism - 4 Apr 2017

Chambers Adam P, Sorrell Joyce E, Haller April, Roelofs Karen, Hutch Chelsea R, Kim Ki-Suk, Gutierrez-Aguilar Ruth, Li Bailing, Drucker Daniel J, D'Alessio David A, Seeley Randy J, Sandoval Darleen A

Abstract excerpt

Glucagon-like peptide 1 (GLP-1) is necessary for normal gluco-regulation, and it has been widely presumed that this function reflects the actions of GLP-1 released from enteroendocrine L cells. To test the relative importance of intestinal versus pancreatic sources of GLP-1 for physiological regulation of glucose, we administered a GLP-1R antagonist, exendin-[9-39] (Ex9), to mice with tissue-specific reactivation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Gastrointestinal Tract

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Glucagon-Like Peptide-1 Receptor

Share to Glucose Tolerance Test

Share to Injections, Intraperitoneal

Share to Organ Specificity

Share to Pancreas

Source

Open in PubMed Open full text

Identifiers

PMID: 28325479
DOI: 10.1016/j.cmet.2017.02.008
PMCID: PMC5385998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.PMID 28325479Read ↗

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.Semantic proximity Read ↗

GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor.Semantic proximity Read ↗

Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.Semantic proximity Read ↗

Beta-cell expression of a dominant-negative HNF-1alpha compromises the ability of inhibition of dipeptidyl peptidase-4 to elicit a long-term augmentation of insulin secretion in mice.Semantic proximity Read ↗

Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.Semantic proximity Read ↗

G protein-coupled receptor 17 inhibits glucagon-like peptide-1 secretion via a Gi/o-dependent mechanism in enteroendocrine cellsSemantic proximity Read ↗

GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ channel.Semantic proximity Read ↗

Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function.Semantic proximity Read ↗

Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency.Semantic proximity Read ↗

Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells.Semantic proximity Read ↗

Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.Semantic proximity Read ↗

Encapsulated, genetically engineered cells, secreting glucagon-like peptide-1 for the treatment of non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.