Article
Genetic polymorphisms in APE1 are associated with renal cell carcinoma risk in a Chinese population.
Molecular carcinogenesis - 1 Nov 2011
Cao Qiang, Qin Chao, Meng Xiaoxin, Ju Xiaobing, Ding Qi, Wang Meilin, Zhu Jian, Wang Wei, Li Pu, Chen Jiawei, Zhang Zhengdong, Yin Changjun
Abstract excerpt
Apurinic/apyrimidinic endonuclease 1 (APE1) is a DNA repair protein, which plays important roles in the base excision repair (BER) pathway. Genetic variations of APE1 have been shown to influence an individual's susceptibility to carcinogenesis. We hypothesized the genetic polymorphisms of APE1 are associated with the risk of renal cell carcinoma (RCC). In a case-control study of 612 RCC patients and 632 age and...
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