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A polymorphism in the APE1 gene promoter is associated with lung cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2009

Lo Yen-Li, Jou Yuh-Shan, Hsiao Chin-Fu, Chang Gee-Chen, Tsai Ying-Huang, Su Wu-Chou, Chen Kuan-Yu, Chen Yuh-Min, Huang Ming-Shyan, Hu Chi Yuan, Chen Chien-Jen, Hsiung Chao A

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway, which is the primary mechanism for the repair of DNA damage caused by oxidation and alkylation. We hypothesized that polymorphisms of APE1 are associated with risk for lung cancer. In the hospital-based matched case-control study, a total of 730 lung cancer cases and 730 cancer-free controls were genotyped for...

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Identifiers

PMID: 19124501
DOI: 10.1158/1055-9965.EPI-08-0749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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