Article
Genetic variant in APE1 gene promoter contributes to cervical cancer risk.
American journal of obstetrics and gynecology - 1 Oct 2013
Wang Miaomiao, Chu Haiyan, Wang Shizhi, Wang Meilin, Wang Wei, Han Suping, Zhang Zhengdong
Abstract excerpt
OBJECTIVE: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway, which plays an important role in repairing DNA damage caused by oxidation and alkylation. However, the exact mechanism of APE1 associated with cervical cancer risk is still unknown. In this study, we explored whether the APE1 -656T>G polymorphism contributed to the risk of cervical cancer. STUDY...
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