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The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

21 Dec 2023

Abstract excerpt

The non-canonical BAF complex (ncBAF) subunit BRD9 is essential for acute myeloid leukemia (AML) cell viability but has an unclear role in leukemogenesis. Because BRD9 is required for ncBAF complex assembly through its DUF3512 domain, precise bromodomain inhibition is necessary to parse the role of BRD9 as a transcriptional regulator from that of a scaffolding protein. To understand the role of BRD9 bromodomain...

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PMID: 38126767
DOI: 10.1158/2767-9764.crc-23-0382

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