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Article

SV40 T antigen <i>alone</i> drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts

1 Jan 1990

Abstract excerpt

To define the role of SV40 large T antigen in the transformation and immortalization of human cells, we have constructed a plasmid lacking most of the unique coding sequences of small t antigen as well as the SV40 origin of replication. The promoter for T antigen, which lies within the origin of replication, was deleted and replaced by the Rous sarcoma virus promoter. This minimal construct was co-electroporated...

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PMID: 2153691
DOI: 10.1002/jcb.240420103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SV40 T antigen <i>alone</i> drives karyotype instability that precedes neoplastic transformation of human diploid fibroblastsPMID 2153691Read ↗

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