Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53.

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Article

Induction of genomic instability in SV40 transformed human cells: sufficiency of the N-terminal 147 amino acids of large T antigen and role of pRB and p53.

Oncogene - 1 Oct 1994

Woods C, LeFeuvre C, Stewart N, Bacchetti S

Abstract excerpt

Genomic instability is an early event in the transformation of human cells by SV40 and may contribute, as a mutagenic process, to the generation of the rare cells which survive crisis and yield immortal populations. We have previously reported that expression of large T antigen is responsible for...

Topics

Amino Acids
Animals
Antigens, Polyomavirus Transforming
Cell Line, Transformed
Cell Transformation, Viral
Genome, Human
Humans
Karyotyping
Mutation
Protein Binding
Rats
Retinoblastoma Protein
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8084597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8084597-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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