Article
Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells.
Virology - 1 Jan 1991
Stewart N, Bacchetti S
Abstract excerpt
Expression of the Simian virus 40 (SV40) early region in human cells results in the induction of chromosomal aberrations and polyploidy, and in transformation. To understand how genetic damage occurs and what role it plays in transformation, human diploid fibroblasts and embryonic kidney cells we...
Topics
- Antibodies, Monoclonal
- Antigens, Polyomavirus Transforming
- Cell Transformation, Viral
- Cells, Cultured
- Chromosome Aberrations
- Cytogenetics
- DNA Replication
- DNA, Viral
- Electrophoresis, Polyacrylamide Gel
- Fibroblasts
- Humans
- Kidney
- Mutation
- Plasmids
- Simian virus 40
- Transfection