Extension of lifespan of human T lymphocytes by transfection with SV40 large T antigen.

doi:10.1016/0014-4827(92)90450-m

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Article

Extension of lifespan of human T lymphocytes by transfection with SV40 large T antigen.

Experimental cell research - 1 Apr 1992

Ryan Q C, Goonewardene I M, Murasko D M

Abstract excerpt

Lymphocytes have a finite and predictable proliferative life span in culture similar to that observed in fibroblasts. In general, the senescence of human fibroblasts is inevitable and irreversible, but their proliferative life span can be extended by certain DNA tumor virus oncogenes, such as the large T antigen of the SV40 virus. Here, we show that human T lymphocytes (HTL) can be stably transfected with SV40...

Topics

Adult
Aged
Animals
Antigens, Polyomavirus Transforming
Cell Division
Cell Line
Cell Transformation, Viral
Cellular Senescence
DNA Tumor Viruses
Female
Flow Cytometry
Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Mice

Nucleic Acid Hybridization

Oncogenes

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1544379
DOI: 10.1016/0014-4827(92)90450-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1544379-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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