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Article

Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts.

Cytometry - 1 Apr 1998

Ray F A, Waltman M J, Lehman J M, Little J B, Nickoloff J A, Kraemer P M

Abstract excerpt

The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony formation in reduced serum growth factors, immortalization, or tumorigenicity. Therefore, chromosome damage may be important in acquiring these traits because it could...

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PMID: 9551599

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Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts.PMID 9551599Read ↗

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