Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts.

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Article

Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts.

Cytometry - 1 Apr 1998

Ray F A, Waltman M J, Lehman J M, Little J B, Nickoloff J A, Kraemer P M

Abstract excerpt

The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony formation in reduced serum growth factors, immor...

Topics

Amino Acid Substitution
Aneuploidy
Antigens, Polyomavirus Transforming
Chromosome Aberrations
Clone Cells
Flow Cytometry
Gene Expression
Genes, Viral
Humans
Mutagenesis, Site-Directed
Mutation
Phenotype
Protein Binding
Simian virus 40
Transfection
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 9551599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9551599-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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