Article
Stepwise transformation of astrocytes by simian virus 40 large T antigen and epidermal growth factor receptor overexpression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1996
Frisa P S, Walter E I, Ling L, Kung H J, Jacobberger J W
Abstract excerpt
We have investigated the transformed phenotype of neonatal mouse cortical astrocytes immortalized by retrovirus-mediated transfer of the SV40 large T antigen gene. Expression of T antigen was driven by the Moloney murine leukemia virus long terminal repeat. Cell lines were selected based on coexp...
Topics
- Animals
- Animals, Newborn
- Antigens, Polyomavirus Transforming
- Astrocytes
- Cell Division
- Cell Transformation, Viral
- Cellular Senescence
- Clone Cells
- Contact Inhibition
- DNA, Recombinant
- ErbB Receptors
- Gene Expression Regulation, Viral
- Genome
- Humans
- Mice
- Mice, Inbred C57BL
- Phenotype
- Ploidies