Iterative chromosome mutation and selection as a mechanism of complete transformation of human diploid fibroblasts by SV40 T antigen.

doi:10.1093/carcin/14.8.1511

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Article

Iterative chromosome mutation and selection as a mechanism of complete transformation of human diploid fibroblasts by SV40 T antigen.

Carcinogenesis - 1 Aug 1993

Ray F A, Kraemer P M

Abstract excerpt

The acquisition of an extended lifespan and of neoplastic properties, including anchorage independence, ability to grow in low serum-containing media, morphological transformation, immortalization and tumorigenicity in nude mice were studied in 31 human fibroblast lineages transfected with plasmids containing the SV40 early genes. Plasmids were used that contained sequences for large T alone, or large T plus...

Topics

Antigens, Polyomavirus Transforming
Cell Transformation, Viral
Cells, Cultured
Chromosomes, Human
Diploidy
Fibroblasts
Gelatin
Humans
Models, Biological
Mutation
Phenotype
Reproducibility of Results
Transfection

Source

Open in PubMed

Identifiers

PMID: 8353836
DOI: 10.1093/carcin/14.8.1511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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