SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.

doi:10.1038/sj.onc.1209046

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Article

SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.

Oncogene - 21 Nov 2005

Ahuja Deepika, Sáenz-Robles M Teresa, Pipas James M

Abstract excerpt

DNA tumor viruses such as simian virus 40 (SV40) express dominant acting oncoproteins that exert their effects by associating with key cellular targets and altering the signaling pathways they govern. Thus, tumor viruses have proved to be invaluable aids in identifying proteins that participate in tumorigenesis, and in understanding the molecular basis for the transformed phenotype. The roles played by the...

Topics

Animals
Antigens, Polyomavirus Transforming
Cell Transformation, Neoplastic
Gene Expression Regulation
Genes, Retinoblastoma
Genes, p53
Hyperplasia
Mice
Mice, Transgenic
Neoplasm Invasiveness
Neoplasm Metastasis
Oncogene Proteins
Phenotype

Source

Open in PubMed

Identifiers

PMID: 16299533
DOI: 10.1038/sj.onc.1209046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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