SV40 17KT antigen complements dnaj mutations in large T antigen to restore transformation of primary human fibroblasts.

Abstract excerpt

Transformation of human cells requires both SV40 large T and small t antigens. Plasmids that contained mutations in the amino-terminal dnaJ domain of the early region fail to transform human diploid fibroblasts. However, large T dnaJ mutants can be rescued by plasmids that express early region products other than large T antigen. The protein found to be responsible for such complementation was the third early...

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