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Article

Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells

22 Oct 2015

Abstract excerpt

BACKGROUND: Despite over 50 years of research, it remains unclear how the DNA tumor viruses SV40 and Polyoma cause cancers. Prevailing theories hold that virus-coded Tumor (T)-antigens cause cancer by inactivating cellular tumor suppressor genes. But these theories don't explain four characteristics of viral carcinogenesis: (1) less than one in 10,000 infected cells become cancer cells, (2) cancers have complex...

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PMID: 26500699
DOI: 10.1186/s13039-015-0183-y

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