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Article

Molecular morphometric analysis shows relative intra-tumoural homogeneity for KRAS mutations in colorectal cancer.

Virchows Archiv : an international journal of pathology - 1 Nov 2011

Farber Liora, Efrati Edna, Elkin Hela, Peerless Yehudit, Sabo Edmond, Ben-Izhak Ofer, Hershkovitz Dov

Abstract excerpt

KRAS mutation status has a significant role determining anti-epidermal growth factor receptor (anti-EGFR) treatment response in colon carcinoma patients. Malignant transformation is a dynamic process and therefore, it is conceivable that, at a certain point, the tumor cells' mass might be heterogeneous for particular mutations. Therefore, the fraction of tumor cells carrying a particular mutation may be more...

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Identifiers

PMID: 22016105
DOI: 10.1007/s00428-011-1158-y

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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