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Article

Intratumorous heterogeneity for RAS mutations in a treatment-naïve colorectal tumour.

Journal of clinical pathology - 1 Aug 2017

Lunke Sebastian, Lee Belinda, Kranz Sevastjan, Gibbs Peter, Waring Paul, Christie Michael

Abstract excerpt

Activating mutations in KRAS and NRAS genes in patients with colorectal cancer (CRC) are associated with a lack of response to treatment with anti-epidermal growth factor receptor (EGFR) therapies. Mutations in these genes are thought to be mutually exclusive, however reports have described CRCs with two activating rat sarcoma (RAS) mutations. This has fuelled discussion about whether these mutations are the...

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Identifiers

PMID: 28314739
DOI: 10.1136/jclinpath-2017-204327

Genes

EGFR
KRAS
NRAS

Provenance

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