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Article

Dynamics of cancer cell subpopulations in primary and metastatic colorectal tumors.

Clinical & experimental metastasis - 1 Jun 2011

Goranova Teodora Evgenieva, Ohue Masayuki, Shimoharu Yutaro, Kato Kikuya

Abstract excerpt

Intratumor heterogeneity-heterogeneity of cancer cells within a single tumor-is considered one of the most problematic factors of treatment. Genetic heterogeneity, such as in somatic mutations and chromosome aberrations, is a common characteristic of human solid tumors and is probably the basis of biological heterogeneity. Using mutations in APC, TP53 and KRAS as markers to identify distinct colorectal cancer...

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Source

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Identifiers

PMID: 21380628
DOI: 10.1007/s10585-011-9381-0
PMCID: PMC3081061

Genes

KRAS
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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