Article
Effect of CYP3A4*1G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population.
Journal of clinical pharmacy and therapeutics - 1 Apr 2012
Dong Z-L, Li H, Chen Q-X, Hu Y, Wu S-J, Tang L-Y, Gong W-Y, Xie G-H, Fang X-M
Abstract excerpt
WHAT IS KNOWN AND OBJECTIVE: Clinical investigations into postoperative intravenous patient-controlled analgesia (PCA) have indicated interindividual differences in fentanyl consumption. Cytochrome P450 3A4 (CYP3A4) is the main metabolism enzyme of fentanyl, and single nucleotide polymorphisms within the CYP3A4 gene may contribute to the variability of fentanyl analgesic efficacy. The aim of this study was to...
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