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Article

Cytochrome P450 3A4 genetic polymorphisms and post-operative fentanyl requirements.

Journal of clinical pharmacy and therapeutics - 1 Feb 2012

Tan P C S, Hassan S K, Mohamad N A N, Gan S H

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Interindividual variability in drug responses may be attributable to genetically determined alteration in enzyme activity. In this study, we investigated the association between cytochrome P450 3A4 (CYP3A4) genetic polymorphisms and post-operative fentanyl requirements. METHODS: Patients (n = 94) scheduled for gynaecological laparotomy received i.v. fentanyl infusion (3 μg/kg/h) after...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21128989
DOI: 10.1111/j.1365-2710.2010.01232.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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