Article
CYP3A4 gene polymorphism is correlated with individual consumption of sufentanil.
Acta anaesthesiologica Scandinavica - 1 Nov 2018
Lv J, Liu F, Feng N, Sun X, Tang J, Xie L, Wang Y
Abstract excerpt
BACKGROUND: Pain is one of the major adverse clinical outcomes of cesarean section (CS). In the past few years, researchers and physicians have been optimizing post-operative analgesic modalities, but the results are still undesirable for the parturient. The cytochrome P-450 3A4 (CYP3A4) gene has been reported to contribute significantly to human liver microsomal oxidation of sufentanil and alfentanil. METHODS:...
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