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Article

Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery.

BMC medical genetics - 23 Nov 2016

Yuan Jing-Jing, Ma Xiao-Jing, Li Zhi-Song, Chang Yan-Zi, Zhang Wei, Kan Quan-Cheng, Hou Jun-Kai, Zhang Li-Rong

Abstract excerpt

BACKGROUND: The purpose of the study was to investigate the effects of the pregnane X receptor (PXR)*1B polymorphisms on CYP3A4 enzyme activity and postoperative fentanyl consumption in Chinese patients undergoing gynecological surgery. METHODS: A total of 287 females of Han ethnicity, aged 20 to 50 years old, ASA I or II, scheduled to abdominal total hysterectomy or myomectomy under general anesthesia were...

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Identifiers

PMID: 27876007
DOI: 10.1186/s12881-016-0348-5
PMCID: PMC5120516

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