Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients.

International journal of clinical pharmacology and therapeutics - 1 May 2013

Kim Kye-Min, Kim Ho-Sook, Lim Se Hun, Cheong Soon Ho, Choi Eun-Jung, Kang Hyun, Choi Hey-Ran, Jeon Jin-Woo, Yon Jun Heum, Oh Minkyung, Shin Jae-Gook

Abstract excerpt

OBJECTIVE: Fentanyl, a μ-opioid receptor agonist, is a substrate of P-glycoprotein. Its metabolism is catalyzed by CYP3A4 and CYP3A5. The aim of this study was to investigate the association between postoperative fentanyl consumption and genetic polymorphisms of μ-opioid receptor (OPRM1), ABCB1 (gene encoding P-glycoprotein), CYP3A4 and CYP3A5 in Korean patients. METHODS: 196 female patients scheduled to undergo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Fentanyl

Share to Laparoscopy

Share to Pain Measurement

Share to Pain, Postoperative

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 23557865
DOI: 10.5414/CP201824

Genes

ABCB1
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients.PMID 23557865Read ↗

Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery.Semantic proximity Read ↗

Effect of CYP3A4*18B polymorphisms and interactions with OPRM1 A118G on postoperative fentanyl requirements in patients undergoing radical gastrectomy.Semantic proximity Read ↗

The impact of genetic variation on sensitivity to opioid analgesics in patients with postoperative pain: a systematic review and meta-analysis.Semantic proximity Read ↗

Effect of CYP3A4*1G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population.Semantic proximity Read ↗

Genotyping test with clinical factors: better management of acute postoperative pain?Semantic proximity Read ↗

Influence of CYP3A5*3 polymorphism and interaction between CYP3A5*3 and CYP3A4*1G polymorphisms on post-operative fentanyl analgesia in Chinese patients undergoing gynaecological surgery.Semantic proximity Read ↗

Association between MDR1/CYP3A4/OPRM1 gene polymorphisms and the post-caesarean fentanyl analgesic effect on Chinese women.Semantic proximity Read ↗

Influence of UGT2B7, OPRM1 and ABCB1 gene polymorphisms on postoperative morphine consumption.Semantic proximity Read ↗

Cytochrome P450 3A4 genetic polymorphisms and post-operative fentanyl requirements.Semantic proximity Read ↗

Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study.Semantic proximity Read ↗

Review of Opioid Pharmacogenetics and Considerations for Pain ManagementSemantic proximity Read ↗

Environmental and genetic factors associated with morphine response in the postoperative period.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.