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Article

The impact of genetic variation on sensitivity to opioid analgesics in patients with postoperative pain: a systematic review and meta-analysis.

Pain physician - 1 Jan 2000

Ren Zhen-Yu, Xu Xiao-Qing, Bao Yan-Ping, He Jie, Shi Le, Deng Jia-Hui, Gao Xue-Jiao, Tang Hui-Lin, Wang Yu-Mei, Lu Lin

Abstract excerpt

BACKGROUND: Individual response to opioid analgesics varies among patients. OBJECTIVE: This study sought to clarify the impact of distinct genetic variations on pain, opioid consumption, and opioid side effects in patients with postoperative pain. STUDY DESIGN: A systematic review and meta-analysis of associations between genetic single-nucleotide polymorphisms (SNPs) and opioids used for acute postoperative...

Read the complete abstract on PubMed

Topics

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Share to Analgesics, Opioid
Share to OPRM1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Pain Management

Share to Pain, Postoperative

Share to Polymorphism, Single Nucleotide

Share to Randomized Controlled Trials as Topic

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 25794200

Genes

OPRM1
ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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