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Article

Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.

Cancer research - 15 Feb 1990

Tada M, Omata M, Ohto M

Abstract excerpt

The ras gene is one of the oncogenes most commonly detected in human cancers, and it consists of three families (H-ras, K-ras, N-ras). These genes are converted to active oncogenes by point mutations occurring in either codon 12, 13, or 61. We analyzed mutations of these codons in 23 primary hepatic malignant tumors (12 hepatocellular carcinomas, nine cholangiocarcinomas, and two hepatoblastomas) by a method to...

Topics

Adenoma, Bile Duct
Adult
Aged
Aged, 80 and over
Base Sequence
Carcinoma, Hepatocellular
Codon
Female
Genes, ras
Humans
Liver Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

RNA, Messenger

Source

Identifiers

PMID: 2153451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2153451-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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