Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas.

doi:10.1016/0168-8278(92)90181-n

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Article

Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas.

Journal of hepatology - 1 Mar 1992

Challen C, Guo K, Collier J D, Cavanagh D, Bassendine M F

Abstract excerpt

DNA from human hepatocellular carcinomas (HCC) were analysed for the presence of mutations in codons 12 and 61 of the K-ras, H-ras and N-ras genes. The relevant ras sequences were amplified in vitro using the polymerase chain reaction and point mutations detected by selective hybridisation using...

Topics

Aged
Base Sequence
Carcinoma, Hepatocellular
Codon
DNA, Neoplasm
Female
Genes, ras
Humans
Liver Neoplasms
Male
Middle Aged
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction

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