Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method.

doi:10.1093/ajcp/100.6.686

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Article

Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method.

American journal of clinical pathology - 1 Dec 1993

Lin S Y, Chen P H, Wang C K, Liu J D, Siauw C P, Chen Y J, Yang M J, Liu M H, Chen T C, Chang J G

Abstract excerpt

A rapid, simple, and nonradioactive method for diagnosing point mutations of c-K-ras oncogenes in gastroenterologic cancers is described. This method involved the selective amplification of DNA fragments from cancer tissues of surgical specimens with specific oligonucleotide primers, followed by...

Topics

Amino Acid Sequence
Gastrointestinal Neoplasms
Genes, ras
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Restriction Mapping

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