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Article

Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method.

American journal of clinical pathology - 1 Dec 1993

Lin S Y, Chen P H, Wang C K, Liu J D, Siauw C P, Chen Y J, Yang M J, Liu M H, Chen T C, Chang J G

Abstract excerpt

A rapid, simple, and nonradioactive method for diagnosing point mutations of c-K-ras oncogenes in gastroenterologic cancers is described. This method involved the selective amplification of DNA fragments from cancer tissues of surgical specimens with specific oligonucleotide primers, followed by digestion with restriction enzymes that recognized artificially created or naturally occurring restriction sites. To...

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Identifiers

PMID: 8249918
DOI: 10.1093/ajcp/100.6.686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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