Article
High incidence of ras gene mutation in intrahepatic cholangiocarcinoma.
Cancer - 1 Mar 1992
Tada M, Omata M, Ohto M
Abstract excerpt
The DNA sequences around codons 12, 13, and 61 of the ras gene were analyzed by polymerase chain reaction and direct sequencing in 18 intrahepatic cholangiocarcinomas. The ras gene mutations were found in 9 of 18 (50%): 6 in K-ras codon 12, 1 in K-ras codon 13, 1 in K-ras codon 61, and 1 in N-ras...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- DNA, Neoplasm
- Female
- Genes, ras
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction