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Article

Analysis of ras gene mutations in gastrointestinal cancers.

Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Dec 1991

Shen C, Chang J G, Lee L S, Yang M J, Chen T C, Lin K Y, Lee M D, Chen P H

Abstract excerpt

Point mutations of c-Ki-ras genes were analyzed in 33 samples of human gastrointestinal malignancy. DNA extracted from the frozen tissue was amplified by polymerase chain reaction (PCR) and analyzed by direct sequencing and slot-blot hybridization at codons 12, 13 and 61 of c-Ki-ras. In 7 cases out of 19 colorectal cancers, point mutations were found: 3 cases at codon 12, 1 at codon 13, 2 at codon 61 of c-Ki-ras...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
DNA Mutational Analysis
Female
Gastrointestinal Neoplasms
Genes, ras
Humans
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Source

Identifiers

PMID: 1686883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1686883-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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