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Article

[Detection of ras gene mutations of primary hepatic malignant tumors by polymerase chain reaction and direct sequencing method].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology - 1 Mar 1990

Tada M, Omata M, Ohto M

Abstract excerpt

Ras genes are converted to active oncogenes by point mutations occurring in either codon 12, 13 or 61. We used polymerase chain reaction and direct sequence method for the analysis of these mutations. We examined 13 hepatocellular carcinomas, 8 cholangiocarcinomas, 2 hepatoblastomas and 1 biliary cystadenocarcinoma. Of these tumors, ras gene mutations were detected solely in cholangiocarcinomas....

Topics

Adenoma, Bile Duct
Adult
Aged
Aged, 80 and over
Codon
DNA Mutational Analysis
DNA, Neoplasm
Female
Genes, ras
Humans
Liver Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Polymerase Chain Reaction

Source

Identifiers

PMID: 2167400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2167400-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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