Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin.

doi:10.1111/1523-1747.ep12874504

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Article

Ras oncogene mutations in basal cell carcinomas and squamous cell carcinomas of human skin.

The Journal of investigative dermatology - 1 Apr 1990

van der Schroeff J G, Evers L M, Boot A J, Bos J L

Abstract excerpt

Activated ras oncogenes have been detected in a variety of human malignancies. Activation of ras oncogenes usually occurs by point mutations within specific codons of the H-ras, N-ras, and K-ras genes. For the present study, DNA was isolated from 30 basal cell carcinomas (BCC) and 12 squamous cel...

Topics

Aged
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Male
Mutation
Polymerase Chain Reaction
Skin Neoplasms

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