Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.

doi:10.1002/1097-0142(19900901)66:5<930::aid-cncr2820660519>3.0.co;2-w

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Article

Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.

Cancer - 1 Sept 1990

Tada M, Yokosuka O, Omata M, Ohto M, Isono K

Abstract excerpt

Ras gene is one of the oncogenes most commonly detected in human cancers and consists of three families (H-ras, K-ras, N-ras) that are converted to active oncogenes by point mutations occurring in codon 12, 13, or 61. The authors analyzed mutations of these codons in 12 extrahepatic bile duct car...

Topics

Adenoma, Islet Cell
Adult
Aged
Bile Duct Neoplasms
Codon
DNA Probes
Female
Gallbladder Neoplasms
Genes, ras
Humans
Male
Middle Aged
Mutation
Pancreatic Neoplasms
Polymerase Chain Reaction
RNA, Messenger

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