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Alzheimer's disease: genetic basis and amyloid imaging as endophenotype.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... - 1 Jun 2011

Berti V, Nacmias B, Bagnoli S, Sorbi S

Abstract excerpt

To date, all known Alzheimer's disease genes inﬂuence amyloid β (Aβ). Imaging of Aβ deposition in the human brain using positron emission tomography (PET) tracers as [11C]Pittsburgh Compound B ([(11)C]PiB) or [18F]FDDNP offers the possibility of using cortical tracer binding as a quantitative endophenotype for genetic studies of late-onset Alzheimer's disease (AD). In this review we investigate the association...

Topics

Aged
Alzheimer Disease
Amyloid beta-Peptides
Apolipoproteins E
Female
Genes, Dominant
Genetic Predisposition to Disease
Humans
Male
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Positron-Emission Tomography

Risk Factors

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PMID: 21532537

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