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Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease.

Biological psychiatry - 15 Nov 2010

Grimmer Timo, Tholen Susanne, Yousefi Behrooz H, Alexopoulos Panagiotis, Förschler Annette, Förstl Hans, Henriksen Gjermund, Klunk William E, Mathis Chester A, Perneczky Robert, Sorg Christian, Kurz Alexander, Drzezga Alexander

Abstract excerpt

BACKGROUND: Pittsburgh Compound B ([¹¹C] PiB) is a specific positron emission tomography (PET) marker of cerebral amyloid deposits. Only few data have been published on in vivo longitudinal changes of amyloid load in Alzheimer's disease (AD) patients, with conflicting results. Therefore, little is known about the factors that influence these changes. METHODS: A group of 24 patients with probable AD diagnosed by...

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Identifiers

PMID: 20598287
DOI: 10.1016/j.biopsych.2010.05.013
PMCID: PMC3045041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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