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Article

Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement.

Brain : a journal of neurology - 1 Jul 2012

Ossenkoppele Rik, Zwan Marissa D, Tolboom Nelleke, van Assema Danielle M E, Adriaanse Sofie F, Kloet Reina W, Boellaard Ronald, Windhorst Albert D, Barkhof Frederik, Lammertsma Adriaan A, Scheltens Philip, van der Flier Wiesje M, van Berckel Bart N M

Abstract excerpt

Alzheimer's disease with early onset often presents with a distinct cognitive profile, potentially reflecting a different distribution of underlying neuropathology. The purpose of this study was to examine the relationships between age and both in vivo fibrillary amyloid deposition and glucose metabolism in patients with Alzheimer's disease. Dynamic [(11)C]Pittsburgh compound-B (90 min) and static...

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PMID: 22556189
DOI: 10.1093/brain/aws113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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