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Article

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease.

Brain : a journal of neurology - 1 Mar 2013

Lehmann Manja, Ghosh Pia M, Madison Cindee, Laforce Robert, Corbetta-Rastelli Chiara, Weiner Michael W, Greicius Michael D, Seeley William W, Gorno-Tempini Maria L, Rosen Howard J, Miller Bruce L, Jagust William J, Rabinovici Gil D

Abstract excerpt

The factors driving clinical heterogeneity in Alzheimer's disease are not well understood. This study assessed the relationship between amyloid deposition, glucose metabolism and clinical phenotype in Alzheimer's disease, and investigated how these relate to the involvement of functional networks. The study included 17 patients with early-onset Alzheimer's disease (age at onset <65 years), 12 patients with...

Topics

Aged
Alzheimer Disease
Amyloid
Female
Fluorodeoxyglucose F18
Glucose
Humans
Image Interpretation, Computer-Assisted
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropsychological Tests

Phenotype

Plaque, Amyloid

Positron-Emission Tomography

Radiopharmaceuticals

Source

Open in PubMed Open full text

Identifiers

PMID: 23358601
DOI: 10.1093/brain/aws327
PMCID: PMC3580269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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