Article
Identifying highly heritable brain amyloid phenotypes through mining Alzheimer's imaging and sequencing biobank data.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2022
Bao Jingxuan, Wen Zixuan, Kim Mansu, Zhao Xiwen, Lee Brian N, Jung Sang-Hyuk, Davatzikos Christos, Saykin Andrew J, Thompson Paul M, Kim Dokyoon, Zhao Yize, Shen Li
Abstract excerpt
Brain imaging genetics, an emerging and rapidly growing research field, studies the relationship between genetic variations and brain imaging quantitative traits (QTs) to gain new insights into the phenotypic characteristics and genetic mechanisms of the brain. Heritability is an important measurement to quantify the proportion of the observed variance in an imaging QT that is explained by genetic factors, and...
Topics
- Algorithms
- Alzheimer Disease
- Biological Specimen Banks
- Brain
- Computational Biology
- Humans
- Neuroimaging
- Phenotype
- Polymorphism, Single Nucleotide
- Quantitative Trait, Heritable