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Article

Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer's disease.

BMC medical genomics - 1 Aug 2022

Kim Mansu, Wu Ruiming, Yao Xiaohui, Saykin Andrew J, Moore Jason H, Shen Li

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common type of dementia. AD is characterized by a decline of cognitive function and brain atrophy, and is highly heritable with estimated heritability ranging from 60 to 80[Formula: see text]. The most straightforward and widely used strategy to identify AD genetic basis is to perform genome-wide association study (GWAS) of...

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Identifiers

PMID: 35915443
DOI: 10.1186/s12920-022-01323-8
PMCID: PMC9344647

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