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Article

Endophenotypes in normal brain morphology and Alzheimer's disease: a review.

Neuroscience - 24 Nov 2009

Reitz C, Mayeux R

Abstract excerpt

Late-onset Alzheimer's disease is a common complex disorder of old age. Though these types of disorders can be highly heritable, they differ from single-gene (Mendelian) diseases in that their causes are often multifactorial with both genetic and environmental components. Genetic risk factors that have been firmly implicated in the cause are mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1)...

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Source

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Identifiers

PMID: 19362127
DOI: 10.1016/j.neuroscience.2009.04.006
PMCID: PMC2812814

Genes

APOE
APP
PSEN1
PSEN2
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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