Article
11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia.
Clinical interventions in aging - 1 Jan 2017
Youn Young Chul, Jang Jae-Won, Han Su-Hyun, Kim HyeRyoun, Seok Ju-Won, Byun Jun Soo, Park Kwang-Yeol, An Seong Soo A, Chun In Kook, Kim SangYun
Abstract excerpt
PURPOSE: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent. METHODS: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients...
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