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Article

The nuclear receptor CAR modulates alcohol-induced liver injury.

Laboratory investigation; a journal of technical methods and pathology - 1 Aug 2011

Chen Xiaosong, Meng Zhipeng, Wang Xiaoqiong, Zeng Samuel, Huang Wendong

Abstract excerpt

The constitutive androstane receptor (CAR) is a member of the nuclear receptor superfamily and a sensor and detoxifier of both xenobiotics and endobiotics. Recent studies also show that CAR participates in metabolism of glucose and lipid, and has an important role in fatty liver disease and diabetes. In this study, we investigate the roles of CAR in chronic and acute alcohol-induced liver injuries. The results...

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Source

Identifiers

PMID: 21519326
DOI: 10.1038/labinvest.2011.68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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