Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

18 Mar 2003

Abstract excerpt

Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. The orphan nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) were originally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Hormonal Regulation and Hypertension
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12644700
DOI: 10.1073/pnas.0438010100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptorPMID 12644700Read ↗

The Nuclear Xenobiotic Receptor Pregnane X Receptor: Recent Insights and New ChallengesSemantic proximity Read ↗

Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: Primary and secondary gene responses with links to disease progressionSemantic proximity Read ↗

Regulation of CAR and PXR Expression in Health and DiseaseSemantic proximity Read ↗

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Semantic proximity Read ↗

PXR: More Than Just a Master Xenobiotic ReceptorSemantic proximity Read ↗

Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolismSemantic proximity Read ↗

Structure and Function of the Human Nuclear Xenobiotic Receptor PXRSemantic proximity Read ↗

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 SuperfamilySemantic proximity Read ↗

Understanding the Physiological Functions of the Host Xenobiotic-sensing Nuclear Receptors PXR and CAR on the Gut Microbiome using Genetically Modified MiceSemantic proximity Read ↗

Orphan Nuclear Receptors: The Exotics of XenobioticsSemantic proximity Read ↗

Pregnane X Receptor as the “Sensor and Effector” in Regulating EpigenomeSemantic proximity Read ↗

Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.