Article
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.
Cancer research - 15 Oct 2004
Yamamoto Yukio, Moore Rick, Goldsworthy Thomas L, Negishi Masahiko, Maronpot Robert R
Abstract excerpt
Hepatocellular carcinoma (HCC) is known to progress through a step often called tumor promotion. Phenobarbital (PB) is the prototype of nongenotoxic cacinogens that promote HCC in rodents. The molecular target of PB to elicit the promotion has been the subject of intense investigations over the last 30 years since it was discovered. The nuclear receptor constitutive active/androstane receptor (CAR) is activated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.