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Article

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Cancer cell - 12 Dec 2016

Kettner Nicole M, Voicu Horatio, Finegold Milton J, Coarfa Cristian, Sreekumar Arun, Putluri Nagireddy, Katchy Chinenye A, Lee Choogon, Moore David D, Fu Loning

Abstract excerpt

Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The process initiates with non-alcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis and fibrosis before HCC detection. This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27889186
DOI: 10.1016/j.ccell.2016.10.007
PMCID: PMC5695235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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