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Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

Hepatology (Baltimore, Md.) - 1 Jul 2006

Baskin-Bey Edwina S, Huang Wendong, Ishimura Norihisa, Isomoto Hajime, Bronk Steven F, Braley Karen, Craig Ruth W, Moore David D, Gores Gregory J

Abstract excerpt

The constitutive androstane receptor (CAR) modulates xeno- and endobiotic hepatotoxicity by regulating detoxification pathways. Whether activation of CAR may also protect against liver injury by directly blocking apoptosis is unknown. To address this question, CAR wild-type (CAR+/+) and CAR knockout (CAR-/-) mice were treated with the CAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) and then with...

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PMID: 16799968
DOI: 10.1002/hep.21236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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