Article

Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors

2020-08-10

Abstract excerpt

<h4>Background and Aims</h4> The xenobiotic nuclear receptor Constitutive Androstane Receptor (CAR) is essential for xenobiotic tumor promotion in mouse models. In these models, β-catenin is genetically activated in approximately 80% of tumors. Chronic Hepatitis B Virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), and β-catenin activation is also frequently activated in HBV-associate...

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Literature Corpus work: 3bb39f1f-7c5e-581e-a5a3-6fe531bfaa4b
DOI: 10.1101/2020.08.08.241661

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