Article

Liver-specific glucocorticoid action in alcoholic liver disease: study of glucocorticoid receptor knockout and knockin mice

2023-10-06

Abstract excerpt

<h4>Background</h4> Glucocorticoids are the only first-line drugs for severe alcoholic hepatitis (AH), with limited efficacy and various side effects on extrahepatic tissues. Liver-targeting glucocorticoid therapy may have multiple advantages over systemic glucocorticoid for AH. The purpose of this study was to determine the role of hepatocellular glucocorticoid receptor (GR) in alcoholic steatosis (AS) and AH. <...

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Literature Corpus work: 039fb07e-8b74-54f8-ab02-4337fb279093
DOI: 10.1101/2023.10.04.557166

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